Balance point characterization of interstitial fluid volume regulation
نویسندگان
چکیده
منابع مشابه
Balance point characterization of interstitial fluid volume regulation.
The individual processes involved in interstitial fluid volume and protein regulation (microvascular filtration, lymphatic return, and interstitial storage) are relatively simple, yet their interaction is exceedingly complex. There is a notable lack of a first-order, algebraic formula that relates interstitial fluid pressure and protein to critical parameters commonly used to characterize the m...
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Under physiological conditions, interstitial fluid volume is tightly regulated by balancing microvascular filtration and lymphatic return to the central venous circulation. Even though microvascular filtration and lymphatic return are governed by conservation of mass, their interaction can result in exceedingly complex behavior. Without making simplifying assumptions, investigators must solve t...
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• In a previous study we found the interstitial fluid pressure, as measured in tissue cavities created by implanting perforated capsules, to be —6 to —7 mm Hg in most normal tissues, though it rose to positive values in edema. Very slight changes of interstitial fluid volume changed the interstitial fluid pressure markedly in normal tissues but only slightly in edematous tissues. The present st...
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Direct measurements of the dispersal of markers in endolymph have failed to support previously established hypotheses of endolymph homeostasis, specifically longitudinal flow, radial flow, and dynamic flow theories. Rather, they suggest that in the normal state endolymph is maintained without a significant involvement of volume flow at all. Ions appear to be transported into and out of the endo...
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BACKGROUND Control of the extracellular fluid volume is one of the most indispensable issues for homeostasis of the internal milieu. However, complex interdependence of the pressures involved in determination of fluid exchange makes it difficult to predict a steady-state tissue volume under various physiological conditions without mathematical approaches. METHODS Here, we developed a capillar...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2009
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00097.2009